Bacterial resistance and failure of clinical cure could be produced by oxidative stress in patients with diabetes or cardiovascular diseases during fluoroquinolone therapy

Publication date: Available online 5 April 2017
Source:Medical Hypotheses
Author(s): Othoniel H. Aragon-Martinez, Flavio Martinez-Morales, Mario A. Isiordia-Espinoza, Diana Luque Contreras, Juan R. Zapata Morales, Maria L. Gonzalez-Rivera
Fluoroquinolone agents are used widely for the treatment of infectious diseases which are a common cause of deaths around the world. The level of oxidative stress in patients taking fluoroquinolone antibiotics has not been considered as a factor to reduce the clinical efficacy of this kind of drugs. Patients with diabetes and/or cardiovascular diseases present abnormal levels of oxidative stress in the blood stream. In this regards, our hypothesis supposes that the patients with diabetes and/or cardiovascular diseases suffering a bacterial disease could experience a therapeutic failure and bacterial resistance when are treated with fluoroquinolones. The crucial mechanism could be an inefficient blood distribution of the drug via red blood cell dysfunction induced by oxidative stress that might reduce the pharmacokinetic-pharmacodinamic ratios. In this way, we review the scientific information to support our hypothesis alongside possible implications. Additionally, this work exhibits the urgent need of studies considering these conditions for quinolone agents.



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