Chinese data of efficacy of low- and high-dose of iodine-131 for the ablation of thyroid remnant.

Chinese data of efficacy of low- and high-dose of iodine-131 for the ablation of thyroid remnant.

Thyroid. 2017 Apr 12;:

Authors: Ma C, Feng F, Wang S, Fu H, Wu S, Ye Z, Chen S, Wang H

Abstract
BACKGROUND: Chinese data of efficacy of low- and high-dose of radioiodine for thyroid remnant is still absent. The aim of the study is to investigate whether the low-dose of radioiodine is as effective as high-dose for remnant ablation in Chinese patients.
METHODS: Patients presenting for radioiodine ablation in our department were included. Inclusion criteria were an age of 16 years or older; total or near total thyroidectomy; tumor-node-metastasis (TNM) stage of pT1-3, any N stage and M0. All patients were randomly allocated to the high-dose group of 3700 MBq and low-dose group of 1850 MBq for remnant ablation. The response to treatment was defined as successful or unsuccessful after 6-9-month interval. Ablation was considered to be successful if patients fulfilled the following criteria: no tracer uptake in the thyroid bed on diagnosis whole body scanning (WBS) and negative level of serum thyroglobulin (Tg-off).
RESULTS: There were 327 patients enrolled between January 2013 and December 2014. More than 95% had papillary thyroid cancer. Data could be analyzed for 278 cases (mean age: 44 years old, 71.6% women), low-dose group, 155 patients, and high-dose group, 123 patients. The rate of initial successful ablation was 84.2 % in all patients, 82.6% in the low-dose group, and 86.2% in the high-dose group. There was no difference between the two groups (P=0.509).
CONCLUSIONS: In Chinese patients with differentiated thyroid carcinoma, the low dose of 1850 MBq radioiodine activity is as effective as high dose of 3700 MBq for thyroid remnant ablation.

PMID: 28401794 [PubMed - as supplied by publisher]

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