Deficient manipulation of working memory in remitted depressed individuals: Behavioral and electrophysiological evidence

Publication date: Available online 26 April 2017
Source:Clinical Neurophysiology
Author(s): Mingfan Liu, Li Zhou, Xiumei Wang, Ying Jiang, Qiaosheng Liu
ObjectiveThe study aimed to examine whether remitted depressed (RMD) individuals show a dysfunction of valence-dependent manipulation and its neurophysiological correlates.MethodEvent-related potentials were conducted on 25 individuals with remitted depression and 27 controls during a working memory manipulation task. The sorting costs and the P3b and slow wave (SW) amplitudes were analyzed.ResultsCompared to the control subjects, the RMD individuals revealed higher sorting costs, particularly when they were shown negative targets. The control individuals exhibited reduced P3b and SW amplitudes in response to the backward negative pictures, whereas the RMD participants exhibited increased central-parietal and lateral P3b and SW amplitudes in the backward condition. Both groups exhibited overall decreased P3b and SW amplitudes in response to the backward positive pictures.ConclusionsRMD individuals are associated with a deficient manipulation for negative material and an unimpaired manipulation for positive material.SignificanceThis study extends current knowledge that deficits in cognitive control persist after the remission of depressive symptoms.



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