Enhanced Coupling within Gonadotropic and Adrenocorticotropic Axes by Moderate Exercise in Healthy Men.

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Enhanced Coupling within Gonadotropic and Adrenocorticotropic Axes by Moderate Exercise in Healthy Men.

J Clin Endocrinol Metab. 2017 Apr 27;:

Authors: Roelfsema F, Yang RJ, Olson TP, Joyner MJ, Takahashi PY, Veldhuis JD

Abstract
Context: Exercise elicits incompletely defined adaptations of metabolic and endocrine milieu, including the gonadotropic and the corticotropic axes.
Objective: To quantify the impact of acute exercise on coordinate LH and testosterone and ACTH and cortisol secretion in healthy men in relation to age.
Participantsand design: Prospectively randomized, within-subject cross-over, study in 23 men, aged 19-77 yr. Subjects underwent rest and 30 min of mixed exercise at 65% of maximal aerobic capacity with 10-min blood sampling between 0700 and 1300 h 2 wks apart.
Main outcome measures: Incremental changes in LH, testosterone, ACTH and cortisol concentrations, the feedforward and feedback strength between exercise and rest, quantified by approximate entropy (ApEn), and bihormonal synchrony, quantitated by cross ApEn.
Results: Mean hourly exercise-minus-rest LH and ACTH increments increased from -0.055±0.187 to 0.755±0.245 IU/L (P=0.003), and from 2.9±2.2 to 71.2±16.1 ng/L (P<0.0001), respectively, during exercise. Testosterone and cortisol increments increased concurrently from -9.6±16.7 to 47.6±17.1 ng/dL (P<0.0001), and 0.45±0.76 to 7.27±0.64 µg/dL (P<0.0001), respectively. During exercise, feedforward as well as feedback LH-testosterone and ACTH-cortisol cross-ApEn decreased markedly quantifying enhanced hormonal coupling. These dynamic adaptations did not correlate with age, visceral fat, power expended, or estradiol, testosterone, adiponectin, IGF-I, cortisol and TSH.
Conclusion: Acute moderate mixed exercise in healthy men rapidly enhances feedforward LH-T and ACTH-cortisol coordination and reciprocal feedback within the gonadotropic and corticotropic axes. In principle, enhancement of both LH-T and ACTH-cortisol secretory synchrony by exercise could reflect augmented coupling between brain-testicular and brain-adrenal neural outflow.

PMID: 28453740 [PubMed - as supplied by publisher]

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