IgE Sensitization in Relation to Preschool Eczema and Filaggrin Mutation

Publication date: Available online 26 April 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Emma Kristin Johansson, Anna Bergström, Inger Kull, Tomas Lind, Cilla Söderhäll, Marianne van Hage, Magnus Wickman, Natalia Ballardini, Carl-Fredrik Wahlgren
BackgroundEczema (atopic dermatitis) is associated with an increased risk of having IgE antibodies. IgE sensitization may occur through an impaired skin barrier. Filaggrin (FLG) mutation is associated with eczema, and possibly also with IgE sensitization.ObjectiveTo explore the longitudinal relation between preschool eczema and/or FLG mutation and IgE sensitization in childhood.MethodsA total of 3201 children from the BAMSE birth cohort recruited from the general population were included. Regular parental questionnaires identified children with eczema. Blood samples were collected at 4, 8, and 16 years for analysis of specific IgE. FLG mutation analysis was performed on 1890 of the children.ResultsPreschool eczema was associated with IgE sensitization to both food and aeroallergens up to age 16 (overall adjOR 2.30; 95%CI: 2.00-2.66). This association was even stronger among children with persistent preschool eczema. FLG mutation was associated with IgE sensitization to peanut at age 4 years (adjOR 1.88; 95% CI: 1.03-3.44), but not to other allergens up to age 16 years. FLG mutation and preschool eczema were not effect modifiers for the association between IgE sensitization and preschool eczema or FLG mutation, respectively. Sensitized children with preschool eczema were characterized by polysensitization, but no other specific IgE sensitization patterns were found.ConclusionsPreschool eczema is associated with IgE sensitization, to both food and aeroallergens, up to 16 years of age. FLG mutation is associated with IgE sensitization to peanut, but not to other allergens. Sensitized children with preceding preschool eczema are more often polysensitized.

Teaser

Preschool eczema is associated with IgE sensitization to food and aeroallergens. FLG mutation is associated with IgE sensitization to peanut, but not other allergens. Preschool eczema is associated with polysensitization among sensitized children.


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