Mydriatics release from solid and semi-solid ophthalmic formulations using different in vitro methods.

Mydriatics release from solid and semi-solid ophthalmic formulations using different in vitro methods.

Drug Dev Ind Pharm. 2017 Apr 20;:1-23

Authors: Pescina S, Macaluso C, Gioia GA, Padula C, Santi P, Nicoli S

Abstract
The aim of the present paper was the development of semisolid (hydrogels) and solid (film) ophthalmic formulations for the controlled release of two mydriatics: phenylephrine and tropicamide. The formulations - based on polyvinylalchol and hyaluronic acid - were characterized, and release studies were performed with three different in vitro set-ups, i.e. Franz-type diffusion cell, vial method and inclined plane; for comparison, a solution and a commercial insert, both clinically used to induce mydriasis, were evaluated. Both gels and film allowed for a controlled release of drugs, appearing a useful alternative for mydriatics administration. However, the release kinetic was significantly influenced by the method used, highlighting the need for optimization and standardization of in vitro models for the evaluation of drug release from ophthalmic dosage forms.

PMID: 28426341 [PubMed - as supplied by publisher]

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