Primary CNS Lymphomas of the brain: a Retrospective Analysis in a Single Institute.

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Primary CNS Lymphomas of the brain: a Retrospective Analysis in a Single Institute.

World Neurosurg. 2017 Mar 28;:

Authors: Lin TK, Yeh TH, Hsu PW, Chuang CC, Tu PH, Chen PY, Jung SM, Wei KC, Huang YC

Abstract
Primary CNS lymphomas (PCNSL) are relatively rare brain tumors. Their accurate diagnosis is mainly by surgical biopsy. In addition to surgical biopsy/decompression, treatment options include high dose methotrexate/chemotherapy and radiation therapy and stem cell therapy. Due to the rarity of this disease, guidelines for PCNSL diagnosis and treatment usually form from a large series of experiences. As a tertiary referral center, we retrospectively reviewed 79 patients during a 13-year period. All patients with PCNSL underwent surgical procedures/bone marrow biopsy procedures, and diagnoses were confirmed by hematologists/neuropathologists. Forty-four patients presented with a single lesion at the time of diagnosis. Only one patient was confirmed positive for HIV. The standard therapy protocol in our institute included high dose methotrexate (intravenous and intrathecal) and chemotherapy with cytosine arabinoside, followed by external irradiation of the brain. The significant prognostic factors were low serum LDH levels and radiation therapy in these patients. Multiplicity of lesions at time of diagnosis did not imply a worse outcome, and surgical resection/debulking did not show a significant survival benefit. PCNSL remains a disease with poor prognosis; further clinical trials and diagnostic tools may be mandatory to reveal the complexity of this disease.

PMID: 28363832 [PubMed - as supplied by publisher]

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