Prognostic factors in head and neck mucosal malignant melanoma.

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Prognostic factors in head and neck mucosal malignant melanoma.

Auris Nasus Larynx. 2017 Apr 03;:

Authors: Çomoğlu Ş, Polat B, Çelik M, Şahin B, Enver N, Keleş MN, Sarı ŞÖ

Abstract
OBJECTIVE: Primary mucosal malignant melanoma of the head and neck (HN-PMMM) is an aggressive and uncommon neoplasm. Herein, we present a series of 33 patients and the results of treatment, and aimed to determine prognostic factors in HN-PMMM.
METHODS: Patients who were diagnosed as having HN-PMMM in our reference hospital, between 2005 and 2014 were evaluated. Thirty-three of these patients who had follow-up data were included. Surgical margin status was extracted from the original pathology reports. Archived materials were retrieved for the histopathologic findings: ulceration, necrosis, lymphovascular invasion, perineural invasion, pigmentation, and presence of an in situ component. Mitotic activity was evaluated using phosphohistone H3 (PHH3) immunohistochemical staining.
RESULTS: We found an association of PHH3 mitotic activity with overall survival in a univariate analysis and to our knowledge, this is the first report among the available case series of HN-PMMM to evaluate mitotic activity using immunohistochemical staining. We also investigated the relationship between multicentricity and locoregional recurrence, which the authors believe is also a first.
CONCLUSION: PHH3 mitotic activity can be used a prognostic factor for head and neck mucosal malignant melanoma.

PMID: 28385366 [PubMed - as supplied by publisher]

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