Successful long-term terbinafine therapy in an asthmatic patient with Aspergillus sensitization and bronchiectasis

Publication date: Available online 25 April 2017
Source:Medical Mycology Case Reports
Author(s): Isabel Rodriguez-Goncer, Rob Niven, David W Denning
Severe asthma with fungal sensitization (SAFS) is estimated to affect ~25% of patients with poorly controlled asthma. Tri-azole therapy is effective in only 60–80% and side effects are common. We report a 25 years-old woman with severe asthma, Aspergillus sensitization and marked bronchiectasis that developed a rare Achilles-tendinopathy with both itraconazole and voriconazole. She started a trial with terbinafine as salvage therapy that led to a striking improvement and long-term control of her respiratory disease.



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