Towards clinical application of RayStretch for heterogeneity corrections in LDR permanent 125I prostate brachytherapy

Publication date: Available online 5 April 2017
Source:Brachytherapy
Author(s): Fernando Hueso-González, Facundo Ballester, Jose Perez-Calatayud, Frank-André Siebert, Javier Vijande
PurposeRayStretch is a simple algorithm proposed for heterogeneity corrections in low-dose–rate brachytherapy. It is built on top of TG-43 consensus data, and it has been validated with Monte Carlo (MC) simulations. In this study, we take a real clinical prostate implant with 71 ¹²⁵I seeds as reference and we apply RayStretch to analyze its performance in worst-case scenarios.Methods and MaterialsTo do so, we design two cases where large calcifications are located in the prostate lobules. RayStretch resilience under various calcification density values is also explored. Comparisons against MC calculations are performed.ResultsDose–volume histogram–related parameters like prostate D90, rectum D2cc, or urethra D10 obtained with RayStretch agree within a few percent with the detailed MC results for all cases considered.ConclusionsThe robustness and compatibility of RayStretch with commercial treatment planning systems indicate its applicability in clinical practice for dosimetric corrections in prostate calcifications. Its use during intraoperative ultrasound planning is foreseen.



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