2-3-11. Pairing of kinesthetic illusion induced by visual stimulus and peripheral nerve stimulation causes sustained enhancement of corticospinal tract excitability

Publication date: June 2017
Source:Clinical Neurophysiology, Volume 128, Issue 6
Author(s): Fuminari Kaneko, Ryosuke Takahashi, Eriko Shibata
The aim of the present study was to explore if associative stimulus of the kinesthetic illusion induced by visual stimulus (KiNvis) and peripheral nerve stimulation (PENS) induces the corticospinal excitability change. Twelve healthy subjects participated. To induce KiNvis, the index finger movement was presented on the display, which covered the subject's actual hand. PENS was applied during the index finger flexion phase in the movie at the 90% intensity of the motor threshold for 15min as a main intervention (KiNvis+PENS). As control conditions, KiNvis+shamPENS, and Observation (no KiNvis)+PENS were set. Single and paired-pulse TMS (ISI: 2 and 3ms) were applied as an examination. MEP was recorded from the right first dorsal interosseous (FDI) muscle. Stimulus intensity of single TMS, and the test stimuli of paired-pulse TMS were adjusted to induce MEP of approximately 1mV amplitude at resting condition. MEP after KiNvis+PENS significantly increased for 60min at least, without significant change in KiNvis+ShamPENS and Observation+PENS. Moreover, short-interval intracortical inhibition of 2 and 3ms significantly decreased after intervention. These findings indicated that associative stimulation of KiNvis and PENS induce a sustained enhancement of corticospinal tract excitability, and cognitive effect of kinesthetic perception is crucial.



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