An Elegan(t) Screen for Drug-Microbe Interactions

Publication date: 10 May 2017
Source:Cell Host & Microbe, Volume 21, Issue 5
Author(s): Alison Vrbanac, Justine W. Debelius, Lingjing Jiang, James T. Morton, Pieter Dorrestein, Rob Knight
Microbes affect drug responses, but mechanisms remain elusive. Two papers in Cell exploit C. elegans to infer anticancer drug mechanisms. Through high-throughput screens of drug-microbe-host interactions, García-González et al. (2017) and Scott et al. (2017) determine that bacterial metabolism underpins fluoropyrimidine cytotoxicity, providing a paradigm for unraveling bacterial mechanisms in drug metabolism.

Teaser

Microbes affect drug responses, but mechanisms remain elusive. Two papers in Cell exploit C. elegans to infer anticancer drug mechanisms. Through high-throughput screens of drug-microbe-host interactions, García-González et al. and Scott et al. determine that bacterial metabolism underpins fluoropyrimidine cytotoxicity, providing a paradigm for unraveling bacterial mechanisms in drug metabolism.


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