Clear cell odontogenic carcinoma, diagnostic difficulties. A case report.

Related Articles

Clear cell odontogenic carcinoma, diagnostic difficulties. A case report.

J Stomatol Oral Maxillofac Surg. 2017 May 11;:

Authors: Ordioni U, Benat G, Hadj Saïd M, Gomez-Brouchet A, Chossegros C, Catherine JH

Abstract
INTRODUCTION: Clear cell odontogenic carcinoma (COCC) is a rare tumor described by Hansen et al. in 1985. The clinical and radiological manifestations are multiple and the diagnosis is histological.
OBSERVATION: A 64 years old patient consulted us for a right mandibular osteolytic lesion associated to a homolateral labial hypoesthesia. A biopsy was performed under local anesthesia. Histology was consistent with a metastatic lesion of clear kidney cell carcinoma, COCC, or odontogenic squamous tumor. Additional tests eliminated a metastatic lesion. A wide excision of the lesion by hemi-mandibulectomy associated with lymph node dissection and reconstruction by a fibula osteoseptocutaneous flap was performed. Presence of a fission of the EWSR1 gene on the histological examination of the surgical specimen made the diagnosis of COCC.
DISCUSSION: Our observation illustrates the difficulty of diagnosing COCC. The new contribution of the cytogenetic techniques such as FISH-type techniques makes possible the improvement of the diagnosis.

PMID: 28502762 [PubMed - as supplied by publisher]

http://ift.tt/2qMJdq7