Familial Clustering of Nasopharyngeal Carcinoma in Non-Endemic Area. Report of Three Families

Publication date: May–June 2017
Source:Acta Otorrinolaringologica (English Edition), Volume 68, Issue 3
Author(s): Leydy Mallerling Paredes-Durán, Elvira del Barco-Morillo, María Jesús Baldeón-Conde, Soledad Medina-Valdivieso, María Cecilia Guillen-Sacoto, Juan Jesús Cruz-Hernández
Nasopharyngeal carcinoma is the predominant tumour type arising in the nasopharynx. Its aetiology is multifactorial; racial and geographical distribution, EBV infection and environmental exposure to specific substances are considered risk factors.This condition is endemic in some Asian areas, where a genetic predisposition in its oncogenesis has been established. There is a strong susceptibility between nasopharyngeal carcinoma and HLA, where related specific haplotypes have been found.In areas where the incidence is low, there are few reported cases of families affected. We report 3 cases of families with nasopharyngeal carcinoma among siblings, in the non-Asian population, probably related to EBV infection.



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