HIV Latency Gets a New Histone Mark

Publication date: 10 May 2017
Source:Cell Host & Microbe, Volume 21, Issue 5
Author(s): Bryan C. Nikolai, Qin Feng
Transcriptional latency of integrated HIV-1 provirus represents a major obstacle to curing HIV. In this issue of Cell Host & Microbe, Boehm et al. (2017) identify a new lysine methyltransferase that writes a repressive histone mark associated with HIV-1 latency. The results are important for strategies to pharmacologically reverse HIV-1 latency.

Teaser

Transcriptional latency of integrated HIV-1 provirus represents a major obstacle to curing HIV. In this issue of Cell Host & Microbe, Boehm et al. identify a new lysine methyltransferase that writes a repressive histone mark associated with HIV-1 latency. The results are important for strategies to pharmacologically reverse HIV-1 latency.


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