Immune cell signaling in autoimmune diseases

Publication date: Available online 19 May 2017
Source:Clinical Immunology
Author(s): George C. Tsokos, Noel R. Rose
On September 20, 2016 the American Autoimmune Related Disease Association convened a selected group of16 experts in Washington DC to discuss current issues and future directions of research in autoimmune diseases from the cell signaling perspective. The major topics considered included new findings on the follicular T cell cells in mice, their metabolic patterns and their control by the newly discovered T follicular regulatory cells. Current work on the metabolic pathways deemed important for the function of T cells was presented. The broader implications of these studies on our understanding of human and murine T regulatory cell and current aspects of B cell biology, innate immunity and organ damage were discussed. This document should provide the reader with a quick update on these topics and help instigate novel studies.



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