Management of Glioblastoma Multiforme in the Elderly: a Review of the Literature.

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Management of Glioblastoma Multiforme in the Elderly: a Review of the Literature.

World Neurosurg. 2017 Apr 29;:

Authors: Halani SH, Babu R, Adamson DC

Abstract
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, occurs most commonly in individuals over the age of 65, and is universally fatal. Increasing age compounds the poor prognosis of GBM, as elderly patients have markedly worse outcomes than younger patients. However, many of the studies previously investigating optimal treatment regimens exclude patients over the age of 65 and thus may not represent the best approaches to ensuring prolonged survival with preserved quality of life. This review aims to highlight the current literature on surgical and medical management, including our own experience, for GBM in the elderly, and to provide rational treatment approaches for a vulnerable, often-overlooked, patient population.

PMID: 28465276 [PubMed - as supplied by publisher]

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