Multiple central giant cell tumour lesions are exclusively linked to syndromes related to RAS/MAPK pathway anomalies

We read the article entitled "SH3BP2-encoding exons involved in cherubism are not associated with central giant cell granuloma" by Teixeira et al. with great interest1. They claim that SH3BP2-encoding exons, as involved in cherubism, are not associated with central giant cell granuloma (CGCG). However, only patients with a solitary lesion were included in their study. In the case of multiple lesions, we have observed a relationship with cherubism and RASopathies. Extensive reviews on these conditions have been published by Hyckel et al.

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