Publication date: August 2017
Source:Current Opinion in Neurobiology, Volume 45
Author(s): Kai Zinn, Engin Özkan
The immunoglobulin superfamily (IgSF) encompasses hundreds of cell surface proteins containing multiple immunoglobulin-like (Ig) domains. Among these are neural IgCAMs, which are cell adhesion molecules that mediate interactions between cells in the nervous system. IgCAMs in some vertebrate IgSF subfamilies bind to each other homophilically and heterophilically, forming small interaction networks. In Drosophila, a global 'interactome' screen identified two larger networks in which proteins in one IgSF subfamily selectively interact with proteins in a different subfamily. One of these networks, the 'Dpr-ome', includes 30 IgSF proteins, each of which is expressed in a unique subset of neurons. Recent evidence shows that one interacting protein pair within the Dpr-ome network is required for development of the brain and neuromuscular system.
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- Skin involvement as the first symptom of rapidly p...
- Preclinical pilot study monitoring topical drug pe...
- Topical capsaicin 8% for the treatment of neuropat...
- Integration of reflectance confocal microscopy int...
- Actinic keratosis. Or maybe not?
- Systematic review of the diagnosis of scabies in t...
- Deficiency of filaggrin regulates endogenous cyste...
- Skin involvement as the first symptom of rapidly p...
- A recent-onset ulcerated nodular plaque on the scalp
- Preclinical pilot study monitoring topical drug pe...
- Topical capsaicin 8% for the treatment of neuropat...
- Integration of reflectance confocal microscopy int...
- Actinic keratosis. Or maybe not?
- Systematic review of the diagnosis of scabies in t...
- Osteolytic lesions: osteitis fibrosa cystica in th...
- Streptococcus bovis prosthetic valve endocarditis ...
- Ichthyosis linearis circumflexa with bamboo hair: ...
- A rare case of bilateral lens dislocations
- Novel dermoscopic findings in mudi-chood disease –...
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- Sometimes pain originating from a non-odontogenic ...
- Subclinical hypothyroidism (SCH) has been associat...
- The global state of psoriasis disease epidemiology...
- The global state of psoriasis disease epidemiology...
- Atenolol Versus Propranolol for Treatment of Infan...
- The Growing Toolbox for Protein Synthesis Studies
- Close Encounters – Probing Proximal Proteins in Li...
- Editorial board
- The effect of the essential oils of lavender and r...
- Computer-assisted orthognathic surgery: evaluation...
- Efficient ZnO1-xSx composites from the Zn5(CO3)2(O...
- IFC (editorial board)
- The International Neuropeptide society pages
- Gayle & Richard Olson prize pages
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