Standardization of the apparent diffusion coefficient value of bladder cancer across different centers: Applicability in predicting aggressive pathologic phenotypes

Publication date: Available online 5 May 2017
Source:Clinical Imaging
Author(s): Toshinori Nishizawa, Soichiro Yoshida, Fumitaka Koga, Hiroshi Tanaka, Mihiro Kaga, Kotaro Watanabe, Hiroshi Fukushima, Yasukazu Nakanishi, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Yasuhisa Fujii, Kazunori Kihara
PurposeWe investigated whether the standardized apparent diffusion coefficient (ADC) value reflects bladder cancer characteristics across different centers.MethodsNinety-eight bladder cancer patients underwent MRI at two institutions. Standardized tumor ADC (sT-ADC) was calculated by dividing absolute tumor ADC (aT-ADC) by that of gluteus maximus. We compared ADCs between MRI protocols according to grade and T-stage.ResultsThe differences in aT-ADC between MRI protocols were negated by sT-ADC. The best sT-ADC cut-offs to predict cancer aggressiveness in the development cohort worked in the validation cohort compared to the development cohort.ConclusionStandardized ADC overcomes the incompatibility between different MRI protocols.



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