Publication date: Available online 28 May 2017
Source:Autoimmunity Reviews
Author(s): G. Gravina, C. Wasen, M.J. Garcia-Bonete, M. Turkkila, M.C. Erlandsson, S. Töyrä Silfverswärd, M. Brisslert, R. Pullerits, K.M. Andersson, G. Katona, M.I. Bokarewa
Survivin is a protein functionally important for cell division, apoptosis, and possibly, for micro-RNA biogenesis. It is an established marker of malignant cell transformation. In non-malignant conditions, the unique properties of survivin make it indispensable for homeostasis of the immune system. Indeed, it is required for the innate and adaptive immune responses, controlling differentiation and maintenance of CD4+ and CD8+ memory T-cells, and in B cell maturation. Recently, survivin has emerged as an important player in the pathogenesis of autoimmune diseases. Under the conditions of unreserved inflammation, survivin enhances antigen presentation, maintains persistence of autoreactive cells, and supports production of autoantibodies. In this context, survivin takes its place as a diagnostic and prognostic marker in rheumatoid arthritis, psoriasis, systemic sclerosis and pulmonary arterial hypertension, neuropathology and multiple sclerosis, inflammatory bowel diseases and oral lichen planus. In this review, we summarise the knowledge about non-malignant properties of survivin and focus on its engagement in cellular and molecular pathology of autoimmune diseases. The review highlights utility of survivin measures for clinical applications. It provides rational for the survivin inhibiting strategies and presents results of recent reports on survivin inhibition in modern therapies of cancers and autoimmune diseases.
http://ift.tt/2qoudir
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- Skin involvement as the first symptom of rapidly p...
- Preclinical pilot study monitoring topical drug pe...
- Topical capsaicin 8% for the treatment of neuropat...
- Integration of reflectance confocal microscopy int...
- Actinic keratosis. Or maybe not?
- Systematic review of the diagnosis of scabies in t...
- Deficiency of filaggrin regulates endogenous cyste...
- Skin involvement as the first symptom of rapidly p...
- A recent-onset ulcerated nodular plaque on the scalp
- Preclinical pilot study monitoring topical drug pe...
- Topical capsaicin 8% for the treatment of neuropat...
- Integration of reflectance confocal microscopy int...
- Actinic keratosis. Or maybe not?
- Systematic review of the diagnosis of scabies in t...
- Osteolytic lesions: osteitis fibrosa cystica in th...
- Streptococcus bovis prosthetic valve endocarditis ...
- Ichthyosis linearis circumflexa with bamboo hair: ...
- A rare case of bilateral lens dislocations
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- Title Page/Sections Editors
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