The clinical effect of postoperative hyperbaric oxygen therapy on idiopathic normal pressure hydrocephalus:A retrospective and comparative analysis of 61 patients with ventriculoperitoneal shunt.

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The clinical effect of postoperative hyperbaric oxygen therapy on idiopathic normal pressure hydrocephalus:A retrospective and comparative analysis of 61 patients with ventriculoperitoneal shunt.

World Neurosurg. 2017 May 11;:

Authors: Yang L, Wang X, Li Y, Chen L, Yan Z, She L, Dong J

Abstract
PURPOSE: The aim of the study was to examine the clinical effect of postoperative hyperbaric oxygen (HBO) therapy on symptoms and signs in the ventriculoperitoneal (VP) shunt insertion treatment of idiopathic normal pressure hydrocephalus (iNPH).
MATERIALS AND METHODS: We conducted a retrospective analysis of 61 patients treated at our institution for iNPH since 2007. Patients were stratified into 2 groups according to undergoing pure VP shunt with gravitational valves (Group 1) or combined with postoperative HBO therapy (Group 2). Clinical improvements as well as complications were compared between the two groups.
RESULTS: There is no significant difference between two groups regarding age, sexual proportion, body mass index (BMI), education years and the average NPH scale score before the surgery, as well as the complication rate after the surgery (P＞0.05). On average, the total NPH scale scores were both increased in the 2 groups at 1, 3 and 6 months after shunting, with no significant differences (P＞0.05). However, the group 2 tended to increase more compared with group 1, especially 6 months later after shunting. And the increasing of cognitive functions (CF) was more significant in group 2 (P＜0.05).
CONCLUSIONS: HBO therapy combined with VP shunt is expected to improve the effect of iNPH treatment, especially for the cognitive performance.

PMID: 28502690 [PubMed - as supplied by publisher]

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