The mutational frequency of BRAF and KRAS in low grade serous testicular neoplasms - a case series.

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The mutational frequency of BRAF and KRAS in low grade serous testicular neoplasms - a case series.

Histopathology. 2017 May 19;:

Authors: Gwiti P, Vereczkey I, Cundell D, Aslam S, Clench T, Braybrooke J, Sohail M, Melegh Z

Abstract
AIMS: Low grade serous neoplasms of the testis are rare neoplasms that demonstrate striking morphological similarities with the better-understood ovarian neoplasms. The cell of origin, relation to serous ovarian tumour and the pathogenesis of these neoplasms are not fully established.
METHODS AND RESULTS: As low grade serous ovarian neoplasms are known to harbour mutations in the MAP-kinase pathway, we investigated the involvement of BRAF and KRAS mutations in low grade testicular serous tumour by way of mutational analysis of 7 cases. Mutational analysis was performed by melting curve analysis followed by bidirectional sequencing. Our findings showed BRAF and/or KRAS mutation in 3 of the 7 cases, similar to the proportions reported in low grade ovarian serous neoplasms. Out of these three cases, one showed co-mutation of BRAF and KRAS.
CONCLUSION: This supports the role of aberrant signalling of the MAP-kinase pathway in the pathogenesis of low grade serous testicular neoplasms and provides a genetic link between low grade testicular and ovarian serous tumours. This article is protected by copyright. All rights reserved.

PMID: 28543997 [PubMed - as supplied by publisher]

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