Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis

Publication date: 12 June 2017
Source:Cancer Cell, Volume 31, Issue 6
Author(s): Ana Magalhães, Henrique O. Duarte, Celso A. Reis
Glycosylation alterations are involved in several steps of human cancer pathogenesis. In this issue of Cancer Cell, Agrawal et al. identified the glycosyltransferase FUT8 as a previously unrecognized mediator of melanoma metastasis, establishing core fucosylation as a potential therapeutic target for prevention and treatment of metastatic tumors.

Teaser

Glycosylation alterations are involved in several steps of human cancer pathogenesis. In this issue of Cancer Cell, Agrawal et al. identified the glycosyltransferase FUT8 as a previously unrecognized mediator of melanoma metastasis, establishing core fucosylation as a potential therapeutic target for prevention and treatment of metastatic tumors.


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