Impact of tumor size on the outcome of patients with small renal cell carcinoma.

Impact of tumor size on the outcome of patients with small renal cell carcinoma.

Expert Rev Anticancer Ther. 2017 Jun 08;:

Authors: Abdel-Rahman O

Abstract
BACKGROUND: This study aims to establish a potential correlation between tumor size and outcomes in patients with T1a kidney cancer registered within the surveillance, epidemiology and end results (SEER) database.
METHODS: The SEER database (2004-2013) has been accessed through the SEER*Stat program to determine the correlation between tumor size and kidney cancer-specific survival in patients with T1a kidney cancer. Survival analysis was conducted through the Kaplan-Meier analysis and log-rank testing.
RESULTS: A total of 38,264 patients with T1a kidney cancer were identified in the period from 2004-2013. Five-year kidney cancer-specific survival rates show a progressive decline with increasing tumor size. Moreover, kidney cancer-specific survival has been compared according to the initial local treatment modality (observation, ablation, partial or radical nephrectomy) across different size categories (<1 cm, 1-2 cm, 2-3 cm and 3-4 cm). Survival curves of different treatment modalities were almost overlapping for patients with renal mass <1cm. For patients with tumor size 1-2 cm, treatment modalities were overlapping at the first 60 months, then the curve of observation diverged (P <0.0001). For patients with tumor size 2-3 cm and 3-4 cm, the curve of observation diverged early in the time course (P <0.0001).
CONCLUSION: Primary tumor size is an important factor that should be taken into consideration when evaluating the different treatment options for patients with small kidney cancers.

PMID: 28593803 [PubMed - as supplied by publisher]

http://ift.tt/2rI0cc9