Mitochondrial DNA depletion induces innate immune dysfunction rescued by interferon-γ

Publication date: Available online 17 June 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): John D. Widdrington, Aurora Gomez-Duran, Jannetta S. Steyn, Angela Pyle, Marie-Helene Ruchaud-Sparagano, Jonathan Scott, Simon V. Baudouin, Anthony J. Rostron, John Simpson, Patrick F. Chinnery FMedSci

Teaser

Monocytes from sepsis patients have mitochondrial DNA (mtDNA) depletion and immune deactivation. Here we find that THP-1 cell immune responses are impaired by experimentally depleting mtDNA, through dysregulated immune signalling, and rescued by interferon-γ treatment.


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