Outbreak of immediate-type hydrolyzed wheat protein allergy due to a facial soap in Japan

Wheat proteins in hydrolyzed form have been widely used in cosmetic products. The number of patients allergic to hydrolyzed wheat protein (HWP) in cosmetic products seems to be small in Western countries (see Table E1 and this article's Online Repository at www.jacionline.org). However, in Japan, Fukutomi et al1 first reported 5 Japanese patients with wheat-dependent exercise-induced anaphylaxis (WDEIA) after using the facial soap containing 0.3% of a specific type of HWP, Glupearl 19S, in 2009, and thousands of subjects showed allergic contact urticaria, anaphylaxis, and/or WDEIA after using the soap.

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