Primary cutaneous anaplastic large cell lymphoma treated with low dose methotrexate

Primary cutaneous anaplastic CD30-positive large cell lymphoma is a rare type of non-Hodgkin's lymphoma that is defined by a predominance of large clusters of CD30+ blast cells on histology. Considered a part of the spectrum of CD30+ lymphoproliferative cutaneous processes, this neoplasm often presents clinically in two forms: systemic and primary cutaneous. The diagnosis is confirmed with histologic examination, radiologic imaging, and supportive immunohistochemistry. The primary cutaneous form occurs in the skin with no evidence of disease elsewhere after a thorough workup.

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