Pro- versus Anti-inflammatory Actions of HDLs in Innate Immunity

Publication date: Available online 22 June 2017
Source:Cell Metabolism
Author(s): Chantal Kopecky, Georg Michlits, Marcus D. Säemann, Thomas Weichhart

Teaser

High-density lipoproteins (HDLs) can inhibit inflammatory cytokine expression on innate immune cells, but sometimes they promote cytokine production as suggested in a recent article in Cell Metabolism by van der Vorst et al. (2017). Kopecky et al. point out that the origin, handling, and storage conditions of HDL preparations dictate their functional properties and can specifically affect immune cells to evoke a pro-inflammatory response.


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