Radiotherapy for Anal Cancer: Intensity-Modulated Radiotherapy and Future Directions.

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Radiotherapy for Anal Cancer: Intensity-Modulated Radiotherapy and Future Directions.

Surg Oncol Clin N Am. 2017 Jul;26(3):467-475

Authors: Castaneda SA, Romak LB

Abstract
The treatment of anal cancer has evolved remarkably in the past 30 years. Definitive chemoradiotherapy is the standard of care, allowing organ preservation and maintenance of continence for most patients. This article reviews recent advances in radiotherapy planning and delivery that have resulted in improvements in treatment-related toxicity. Most notably, the advent and wide adoption of intensity-modulated radiotherapy provides a superior toxicity profile compared with older techniques, while maintaining similar oncologic outcomes. Current areas of active research include optimizing and individualizing treatment intensity and possible integration of biologic agents and immunotherapies in the treatment of anal cancer.

PMID: 28576183 [PubMed - in process]

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