The Enteric Toxicity of Gluten Enhances Graft-versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

Publication date: Available online 16 June 2017
Source:Medical Hypotheses
Author(s): Taylor Neuman, Kevin David, Dennis Cooper, Roger Strair
Pro-inflammatory peptides present in wheat and related grains are associated with celiac disease and non-celiac gluten sensitivity. We hypothesize that these peptides induce enteric responses that may exacerbate the gastrointestinal manifestations of graft-versus-host disease after an allogeneic hematopoietic stem cell transplant. Therefore, we propose that a gluten free diet should be tested as a prophylactic and/or therapeutic intervention against gastrointestinal graft-versus-host disease for patients undergoing an allogeneic hematopoietic stem cell transplant.



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