The pancreatic cancer microenvironment: A true double agent.

The pancreatic cancer microenvironment: A true double agent.

J Surg Oncol. 2017 Jun 12;:

Authors: Melstrom LG, Salazar MD, Diamond DJ

Abstract
The tumor microenvironment in pancreatic cancer is a complex balance of pro- and anti-tumor components. The dense desmoplasia consists of immune cells, extracellular matrix, growth factors, cytokines, and cancer associated fibroblasts (CAF) or pancreatic stellate cells (PSC). There are a multitude of targets including hyaluronan, angiogenesis, focal adhesion kinase (FAK), connective tissue growth factor (CTGF), CD40, chemokine (C-X-C motif) receptor 4 (CXCR-4), immunotherapy, and Vitamin D. The developing clinical therapeutics will be reviewed.

PMID: 28605029 [PubMed - as supplied by publisher]

http://ift.tt/2sXcbBi