Appearance of anti-desmocollin 1 autoantibodies leading to a vegetative lesion in a pemphigus vulgaris patient

Abstract

Pemphigus is a group of autoimmune bullous diseases that is mainly classified into pemphigus vulgaris (PV) and pemphigus foliaceus.¹ PV is further subcategorized into a mucocutaneous type (with autoantibodies against desmoglein (Dsg) 3 and Dsg1) and a mucosal type (with autoantibodies against Dsg3 but not Dsg1) based on autoantibody profile and clinical features. Pemphigus vegetans (PVeg), a rare variant of PV, is characterized by vegetating lesions. However, the mechanism behind the occurrence of these elevated lesions remains unclear.² Recently, it was reported that anti-desmocollin (Dsc) 1 and Dsc3 autoantibodies were frequently detected and potentially pathogenic in PVeg.³ Here we report a case of PV in which a vegetative plaque occurred during treatment accompanied by the elevation of anti-Dsc1 autoantibodies.

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