Epigenetics of pituitary tumors: Pathogenetic and therapeutic implications

Publication date: Available online 12 July 2017
Source:Molecular and Cellular Endocrinology
Author(s): Shereen Ezzat, Sonia Cheng, Sylvia L. Asa
Genetic mutations involving oncogenes or tumor suppressor genes are relatively uncommon in human sporadic pituitary tumors. Instead, increasing evidence has highlighted frequent epigenetic alterations including DNA methylation, histone modifications, and enhanced miRNA expression. This review covers some of this evidence as it illuminates mechanisms of tumorigenesis and highlights therapeutic opportunities.



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