Abstract: Methylene blue is a chromophore dye known for its photosensitizing properties. It is also administered intravenously as a tracer in parathyroid surgery to identify abnormal glands. We describe 2 cases of acute methylene blue–induced phototoxicity in patients who underwent parathyroidectomy. Both patients developed an acute vesiculopustular inflammatory rash on the anterior neck corresponding to the site exposed intraoperatively to overhanging surgical lights. One of the patients also developed a bulla on her finger at the site of attachment of the oxygen probe. Biopsies were taken from both patients at different time points. The histological findings included destruction of sebaceous glands and deposition of diastase-periodic acid-Schiff–positive hyaline material around dermal blood vessels. These features are similar to those seen in skin treated with photodynamic therapy and systemic photosensitivity disorders such as the porphyrias. The wavelengths of light emitted by the surgical lights and oxygen probe overlap with the absorption spectrum of methylene blue. This resulted in excitation of the systemically administered methylene blue at exposed sites, with resultant local tissue damage and a phototoxic reaction.
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- Occurrence and distribution of six selected endocr...
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- Using virtual microscopy to deliver an integrated ...
- Public health: Extraordinary heroism
- Revolutionary self-clearing dental mirror
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- Making the most of employee benefits
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- NHS dental service utilisation and social deprivat...
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- Use of cyanoacrylate tissue adhesive to orientate ...
- Management of upper and lower molars that are disp...
- Free flap reconstruction for patients aged 85 year...
- Intraosseous spindle cell lipoma of the mandible: ...
- Severe distortion of an orbital titanium mesh impl...
- Minimally-invasive removal of a screw in the mandi...
- Prevalence of chromosomal aberrations in Argentine...
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