Immunohistochemical Expression of MYB in Salivary Gland Basal Cell Adenocarcinoma and Basal Cell Adenoma

Abstract

Background

Basal cell predominant salivary gland neoplasms can be difficult to separate histologically. One of the most aggressive of basaloid salivary gland neoplasms is adenoid cystic carcinoma. MYB expression by immunohistochemistry has been documented in adenoid cystic carcinoma. Some investigators have suggested that using this expression can help in the establishing the diagnosis of adenoid cystic carcinoma. Utilizing tissue microarrays, we studied a group of basal cell adenocarcinomas and basal cell adenomas to determine: 1) if either tumor expressed MYB, and 2) the frequency of any expression in either.

Methods

Seventeen salivary gland basal cell adenocarcinomas and 30 salivary gland basal cell adenomas were used to construct microarrays. These tissue microarrays were used to assess for immunohistochemical MYB expression.

Results

Fifty-three percent (9/17) of salivary gland basal cell adenocarcinomas and 57% (17/30) of salivary gland basal cell adenomas showed MYB over-expression. For comparison we studied 11 adenoid cystic carcinomas for MYB expression and found that 64% (7/11) over-expressed MYB. We found no relation to clinical course for basal adenomas or basal cell adenocarcinomas that overexpressed MYB versus those that did not.

Conclusions

MYB expression does not help separate basal cell adenocarcinomas from basal cell adenomas and our data suggest it does not differentiate between either of these neoplasms and adenoid cystic carcinoma.

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