Review of Extra-Skeletal Activity on Tc-99m MDP Bone Scintigraphy and Value of Cross-sectional and SPECT-CT Imaging Correlation

Publication date: Available online 31 July 2017
Source:Current Problems in Diagnostic Radiology
Author(s): Mohammed Bermo, Sanaz Behnia, Joanna Fair, Robert S. Miyaoka, Saeed Elojeimy
Recognizing the different mechanisms and imaging appearance of extra-skeletal Tc-99m methylene diphosphonate (MDP) uptake enhances the diagnostic value of bone scan interpretation. In this article, we present a pictorial review of the different mechanisms of extra-skeletal Tc-99m MDP uptake on bone scintigraphy including neoplastic, inflammatory, ischemic, traumatic, excretory, and iatrogenic. We also illustrate through case examples the added value of correlation with cross-sectional and SPECT-CT imaging in localizing and characterizing challenging cases of extra-skeletal uptake.



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