Surgical treatment associated with improved survival in patients with cutaneous angiosarcoma

Abstract

Cutaneous angiosarcoma is a rare aggressive vasoformative neoplasm of the skin with a poor prognosis.¹ The neoplasm preferentially involves areas of head and neck and usually diagnosed in advanced stage.^{1, 2} The neoplasm accounts for only 2% of soft-tissue sarcomas in the U.S. and most often affects elderly white males, patients treated with radiation, and individuals with certain chronic lymphatic disorders.³ Surgery with or without adjuvant or neoadjuvant radiation therapy (RT) is considered the mainstay of therapy.^{1, 3} Due to low incidence rates, the clinical outcomes data has been limited to case reports and single institution studies, with a lack of direct comparison between various treatment modalities: surgery, RT, and chemotherapy (CT).^{4, 5} In this study, we aimed to investigate the impact of undergoing different therapeutic approaches on long-term overall survival (OS) using cross-institutional data.

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