Chronic Sucralose or L-Glucose Ingestion Does Not Suppress Food Intake

Publication date: 1 August 2017
Source:Cell Metabolism, Volume 26, Issue 2
Author(s): Qiao-Ping Wang, Stephen J. Simpson, Herbert Herzog, G. Gregory Neely
Despite widespread consumption of non-nutritive sweeteners (NNSs), the impact of manipulating the perceived sweetness of food is unclear. Previously we reported that chronic consumption of the NNSs sucralose or L-glucose led to increased calories consumed post-exposure; however, a recent study suggested this effect occurs because NNSs acutely suppress food intake, leading to a caloric debt. Here we show that acute ingestion of sucralose in the context of a low-carbohydrate diet causes a pronounced increase in calories consumed. Moreover, neither sucralose nor L-glucose had a lasting effect on food intake during chronic exposure; however, both NNSs enhance food intake post-exposure. Together these data confirm that sucralose and L-glucose promote food intake under a variety of experimental conditions.

Teaser

Wang et al. show that chronic exposure to the non-nutritive sweeteners (NNSs) sucralose or L-glucose promotes food intake post-exposure. Further, in the context of a balanced diet, consumption of NNSs had little immediate effect on appetite; however, on a low-carbohydrate diet, the addition of sucralose acutely increases calories consumed.


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