Cutaneous sporotrichosis treated with methylene blue-daylight photodynamic therapy

Abstract

Sporotrichosis is an infection caused by the dimorphic fungus,Sporothrix schenckii. Acquisition typically occurs via cutaneous inoculation with development of a localized cutaneous and/or lymphocutaneous infection. aPDT (antimicrobial photodynamic therapy) is a process that generates reactive oxygen species (ROS) in presence of a photosensitizer, visible light and oxygen which destroys fungal and bacterial cells(1). Daylight PDT (DL-PDT) uses the visible spectrum of daylight (400-750nm) for the activation of the photosensitizer instead of an artificial light source. It is currently approved to treat actinic keratosis(2). The band of absorption of MB is between 550-700nm, with an absorption peak of 654nm.

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