Publication date: September 2017
Source:Journal of Dairy Science, Volume 100, Issue 9
Author(s): S. Tsuruta, D.A.L. Lourenco, I. Misztal, T.J. Lawlor
The objective of this study was to investigate the feasibility of genomic evaluation for cow mortality and milk production using a single-step methodology. Genomic relationships between cow mortality and milk production were also analyzed. Data included 883,887 (866,700) first-parity, 733,904 (711,211) second-parity, and 516,256 (492,026) third-parity records on cow mortality (305-d milk yields) of Holsteins from Northeast states in the United States. The pedigree consisted of up to 1,690,481 animals including 34,481 bulls genotyped with 36,951 SNP markers. Analyses were conducted with a bivariate threshold-linear model for each parity separately. Genomic information was incorporated as a genomic relationship matrix in the single-step BLUP. Traditional and genomic estimated breeding values (GEBV) were obtained with Gibbs sampling using fixed variances, whereas reliabilities were calculated from variances of GEBV samples. Genomic EBV were then converted into single nucleotide polymorphism (SNP) marker effects. Those SNP effects were categorized according to values corresponding to 1 to 4 standard deviations. Moving averages and variances of SNP effects were calculated for windows of 30 adjacent SNP, and Manhattan plots were created for SNP variances with the same window size. Using Gibbs sampling, the reliability for genotyped bulls for cow mortality was 28 to 30% in EBV and 70 to 72% in GEBV. The reliability for genotyped bulls for 305-d milk yields was 53 to 65% to 81 to 85% in GEBV. Correlations of SNP effects between mortality and 305-d milk yields within categories were the highest with the largest SNP effects and reached >0.7 at 4 standard deviations. All SNP regions explained less than 0.6% of the genetic variance for both traits, except regions close to the DGAT1 gene, which explained up to 2.5% for cow mortality and 4% for 305-d milk yields. Reliability for GEBV with a moderate number of genotyped animals can be calculated by Gibbs samples. Genomic information can greatly increase the reliability of predictions not only for milk but also for mortality. The existence of a common region on Bos taurus autosome 14 affecting both traits may indicate a major gene with a pleiotropic effect on milk and mortality.
http://ift.tt/2wqCAfd
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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! # Ola via Alexandros G.Sfakianakis on Inoreader
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Σάββατο 19 Αυγούστου 2017
Genomic analysis of cow mortality and milk production using a threshold-linear model
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- Covalent and non-covalent chemical engineering of ...
- Reputation Management and Content Control: An Anal...
- Autologous platelet-rich plasma versus conventiona...
- Autologous platelet-rich plasma versus conventiona...
- Effect of different dental burs for experimental i...
- Linkage between human population and trace element...
- Seasonality, diaspore traits and the structure of ...
- Neurobiology of autoimmune encephalitis
- New insights into olivo-cerebellar circuits for le...
- Amino acid functionalized zinc oxide nanostructure...
- Isolated Second Implant Adaptation Period in Seque...
- Musical Rehabilitation in Adult Cochlear Implant R...
- Linking Deafness and Dementia: Challenges and Oppo...
- Breast cancer subtype discrimination using standar...
- Metastable Zr–Nb alloys for spinal fixation rods w...
- The role of inattention and hyperactivity/impulsiv...
- CCR10 activation stimulates the invasion and migra...
- Progesterone therapy induces an M1 to M2 switch in...
- Collagenase treatment enhances proteomic coverage ...
- Degradable bioadhesive nanoparticles for prolonged...
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- Conchal contractility after inferior turbinate hyp...
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- Long-term therapy with intravenous zoledronate inc...
- Determining the fate of cranial sutures after surg...
- Perinatal complications in patients with unisutura...
- Effects of low-level laser therapy and platelet co...
- Development and Validation of a Modular Endoscopic...
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- Significance of Endolymphatic Hydrops in Ears With...
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- Diagnostic implications of TERT promoter mutation ...
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- Spatial variation and toxicity assessment for heav...
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- IFC(EDITORIAL BOARD)
- DNA polymerase ι: the long and the short of it!
- A novel somatic JAK2 kinase-domain mutation in ped...
- Mentalizing regions represent distributed, continu...
- Decoding cognitive concepts from neuroimaging data...
- Suppression of irrelevant sounds during auditory w...
- Unidirectional brain to muscle connectivity reveal...
- MB-SWIFT functional MRI during deep brain stimulat...
- Simultaneous intrinsic signal imaging of auditory ...
- Differential expression of transforming growth fac...
- Evaluation of coronary artery disease as a risk fa...
- Coexistence of congenital left ventricular aneurys...
- Editorial Board
- Table of Contents
- Information for Authors
- Masthead
- Effects of transcranial direct current stimulation...
- Inter-hemispheric control of vestibular thresholds
- Brief rTMS delivered by H-Coil to a healthy volunt...
- Prevalence of high-risk human papillomavirus infec...
- Distribution and controls of heavy metals and orga...
- Mechanisms of Mixed Chimerism-Based Transplant Tol...
- Post-Translational Peptide Splicing and T Cell Res...
- Reproducibility and validity of the Italian versio...
- Coexistence of congenital left ventricular aneurys...
- Carapax Trionycis extracts inhibit fibrogenesis of...
- Berberine activates caspase-9/cytochrome c-mediate...
- Circadian variation in anticonvulsant activity of ...
- Up-regulation of HCRP1 inhibits proliferation and ...
- Phytanic acid induced neurological alterations in ...
- Nrf2 activation is required for curcumin to induce...
- Anti-photoaging potential of propolis extract in U...
- The prognostic landscape of tumor-infiltrating imm...
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- VDAC1 deacetylation is involved in the protective ...
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- The blue skies in Beijing during APEC 2014: A quan...
- Effect of relative humidity on O3 and NO2 oxidatio...
- Nano-sized and other improved reporters for Magnet...
- Experimental cocrystal screening and solution base...
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- Iron deficiency anemia in children with cyanotic c...
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