Lytic eosinophils produce extracellular DNA traps as well as free eosinophil granules

We read with interest the report by Gevaert et al1 on eosinophils in nasal polyps. For decades the senior authors of this article1 have championed roles of eosinophil death through apoptosis. They now report that apoptosis was practically absent in the highly eosinophilic polyps. This concession needs underscoring because it agrees with reports questioning the importance of eosinophil apoptosis in human diseased airway tissues in vivo.2,3 Regarding eosinophil death through lysis, Gevaert et al1 assert "that cell lysis did not occur under the conditions of EET formation." This arguably is a misleading statement.

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