Dancing with the Stars: Phenolic Glycolipids Partners with Macrophages

Publication date: 13 September 2017
Source:Cell Host & Microbe, Volume 22, Issue 3
Author(s): Micah D. Dunlap, Shabaana A. Khader
How Mycobacterium leprae infection causes demyelination to mediate leprosy pathogenesis has been a long-standing question. In a recent Cell paper, Madigan et al. (2017) use a zebrafish model of M. leprae infection to show that infected macrophages patrol axons to trigger mitochondrial damage and induce demyelination of nerve cells.

Teaser

How Mycobacterium leprae infection causes demyelination to mediate leprosy pathogenesis has been a long-standing question. In a recent Cell paper, Madigan et al. (2017) use a zebrafish model of M. leprae infection to show that infected macrophages patrol axons to trigger mitochondrial damage and induce demyelination of nerve cells.


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