Development of a safe and scalable route towards a tau PET tracer precursor

Publication date: Available online 12 October 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Bjoern Bartels, Philipp Cueni, Dieter Muri, Matthias Koerner
A scalable 5-step synthesis of the diazacarbazole derivative 1 used as tau PET tracer precursor is reported. Key features of this synthesis include a Buchwald-Hartwig amination, a Pd catalyzed C-H activation and a Suzuki-Miyaura cross-coupling.

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