Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

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Σάββατο 7 Οκτωβρίου 2017

Neuronal activity patterns in the ventral thalamus: comparison between Parkinson’s disease and cervical dystonia

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Publication date: Available online 7 October 2017
Source:Clinical Neurophysiology
Author(s): Dmitriy Devetiarov, Ulia Semenova, Svetlana Usova, Alexey Tomskiy, Vladimir Tyurnikov, Dinara Nizametdinova, Artem Gushcha, Elena Belova, Alexey Sedov
ObjectiveThe aim of this study was to distinguish neuronal activity patterns in the human ventral thalamus and reveal common and disease-specific features in patients with Parkinson's disease (PD) and cervical dystonia (CD).MethodsSingle unit activity of neurons was recorded during microelectrode-guided thalamotomies. We classified neurons of surgical target and surrounding area into patterns and compared their characteristics and responsiveness to voluntary movement between PD and CD patients.ResultsWe distinguished five patterns of neuronal activity: single, LTS burst, mixed, non-LTS burst and longburst patterns. The burst and mixed patterns showed significant differences in several basic and burst characteristics. We showed that there were no disease-specific patterns or significant differences in pattern distribution between studied patients. However, burst patterns had an unbalanced distribution between disease conditions. In addition, we found difference in LTS burst characteristics between surgical targets and surrounding nuclei. All identified patterns, except the long burst pattern, were reactive to the motor tasks and to contraction of the pathological muscles.ConclusionsThe ventral thalamus was characterised by common neuronal activity patterns which differed in characteristics between PD and CD.SignificanceOur findings highlight patterns of neuronal activity of the human ventral thalamus and specific pathological features.



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