Publication date: December 2017
Source:Biological Psychology, Volume 130
Author(s): Jie Meng, Lei Hao, Dongtao Wei, Jiangzhou Sun, Yu Li, Jiang Qiu
Loneliness is a common experience. Susceptibility to loneliness is a stable trait and is heritable. Previous studies have suggested that loneliness may impact regional gray matter density and brain activation to social stimuli, but its relation to white matter structure and how it may interact with genetic factors remains unclear. In this study, we investigated whether and how a common polymorphism (Val66Met) in the brain-derived neurotrophic factor gene modulated the association between loneliness and white matter microstructure in 162 young adults. The tract-based spatial statistics analyses revealed that the relationships between loneliness and white matter microstructures were significantly different between Val/Met heterozygotes and Val/Val homozygotes. Specifically, loneliness was significantly correlated with reduced fractional anisotropy and increased radial diffusivity in widespread white matter fibers within Val/Met heterozygotes. It was also significantly correlated with increased radial diffusivity in Met/Met genotypes but showed no significant association with white matter measures in Val/Val genotypes. Furthermore, the associations between loneliness and fractional anisotropy (or radial diffusivity) in Val/Met heterozygotes turned out to be global effects. These results provide evidence that loneliness may interact with the BDNF Val66Met polymorphism to shape the microstructures of white matter, and the Val/Met heterozygotes may be more susceptible to social environment.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Η λίστα ιστολογίων μου
Πέμπτη 2 Νοεμβρίου 2017
BDNF Val66Met polymorphism modulates the effect of loneliness on white matter microstructure in young adults
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- Regarding complications following completion lymph...
- Performance and microbial characteristics of bioma...
- Advanced scoring method of eco-efficiency in Europ...
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- Contents
- Management of Anaphylaxis
- Copyright-Page
- Allergy for the Otolaryngologist
- CME Accreditation Page
- Allergy as Part of the Unified Otolaryngologic Pra...
- Contributors
- Allergy for the Otolaryngologist
- Forthcoming Issues
- Rational Approach to Allergy Testing
- Clinical Applications of Sublingual Immunotherapy
- Contents
- Management of Anaphylaxis
- Copyright-Page
- Allergy for the Otolaryngologist
- CME Accreditation Page
- Allergy as Part of the Unified Otolaryngologic Pra...
- Contributors
- Allergy for the Otolaryngologist
- Forthcoming Issues
- Low-level laser therapy prevents endothelial cells...
- Editorial Board/Aims & Scope
- Reconstruction Special Edition, Issue 1
- Reflections: Paul Bernard Chretien, MD (1931-2017)
- A high ratio of IL-12Rβ2-positive tumor-infiltrati...
- Elderly patients affected by head and neck squamou...
- Percutaneous endoscopic gastrostomy feeding of loc...
- The effect of home-based program and outpatient ph...
- Reconstruction design before tumour resection: A n...
- Long-term treatment outcomes and prognosis of muco...
- A pilot study of Merkel cell polyomavirus in squam...
- Synchronous, bilateral tonsillar carcinomas: Patie...
- The incidence and management of non-head and neck ...
- Liquid biopsy: An emerging prognostic and predicti...
- 40-year incidence trends for oropharyngeal squamou...
- A failure-type specific risk prediction tool for s...
- Prognostic value of c-MET in head and neck cancer:...
- Frequent oncogenic BRAF V600E mutation in odontoge...
- Extracapsular extension is associated with worse d...
- Cost-effectiveness of nivolumab for recurrent or m...
- Salivary duct carcinoma: An aggressive salivary gl...
- A study on diffusion and kurtosis features of cerv...
- Synthesis, nature and utility of universal iron ch...
- And yet it moves: Recovery of volitional control a...
- Genioglossus muscle advancement and simultaneous s...
- Fluctuating asymmetry of the normal facial skeleton
- Changes in condylar volume and joint spaces after ...
- On the tracks of sandarac, review and chemical ana...
- A facilitated diffusion mechanism establishes the ...
- Chlorination disinfection by-products and comparat...
- Historical trends of trace metals in muddy deposit...
- Water quality and resource management in the dairy...
- Integrating water quality responses to best manage...
- Electric arc furnace (EAF) dust: Application of ai...
- Contributors
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- Forthcoming Issues
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- Anesthesia Outside the Operating Room
- Demands of Integrated Care Delivery in Interventio...
- Building and Maintaining Organizational Infrastruc...
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- Implementation and Use of Anesthesia Information M...
- Monitoring for Nonoperating Room Anesthesia
- Use of Anesthesiology Services in Radiology
- An Anesthesiologist’s View of Tumor Ablation in th...
- Catheterization Laboratory
- Anesthesia in the Electrophysiology Laboratory
- Cardioversions and Transthoracic Echocardiography
- Copyright
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- Anesthesia Outside of the Operating Room: The Wild...
- Anesthesia Outside the Operating Room
- Anesthesia Outside the Operating Room
- Implementation and Use of Anesthesia Information M...
- Monitoring for Nonoperating Room Anesthesia
- Use of Anesthesiology Services in Radiology
- A Radiologist’s View of Tumor Ablation in the Radi...
- Anesthesia in the Electrophysiology Laboratory
- Cardioversions and Transthoracic Echocardiography
- Anesthesia for Routine and Advanced Upper Gastroin...
- Anesthesia for Colonoscopy and Lower Endoscopic Pr...
- Targeted muscle reinnervation for pain control in ...
- The liquid facelift: first hands-on experience wit...
- Rapidly growing mycobacteria infections among “cos...
- 3D graphene-based nanostructured materials as sorb...
- Microarray analysis of lncRNA and mRNA expression ...
- CORRECTION
- Isotretinoin treatment for acne and risk of depres...
- Gonadotropin regulation by pulsatile GnRH: Signali...
- Sputum cell interleukin-1 receptor expression leve...
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