Publication date: Available online 28 November 2017
Source:The Journal of Steroid Biochemistry and Molecular Biology
Author(s): Simon Travers, Laetitia Martinerie, Pascal Boileau, Qiong-Yao Xue, Marc Lombès, Eric Pussard
Fetal steroidome in late pregnancy receives multiple contributions from both maternal and fetal adrenals as well as from placenta. Depressed glucocorticoid levels have been reported in fetal blood at birth, yet studies on mineralocorticoid pathways are sparse. To investigate biosynthesis pathways at birth, adrenal steroids profiles were established in paired mothers and neonates. Forty-six paired healthy term newborns and their mothers from the Aldo cohort were assessed. Steroidomic profiles of mineralocorticoids, glucocorticoids and adrenal androgens were established from umbilical cord and maternal blood at birth using a highly sensitive and specific LC-MS/MS methodology. As compared to maternal blood, umbilical cord blood exhibited high levels of steroids precursors (progesterone and 11-deoxycorticosterone) contrasting with a collapse in corticosterone levels. Consecutively, 18-hydroxycorticosterone and aldosterone levels were also depressed in neonates. Similarly, umbilical cord blood levels of both 17-hydroxyprogesterone and 11-deoxycortisol were higher while cortisol levels sharply decreased. The product-to-substrate ratios evaluating the 11-hydroxylation step (corticosterone/11-deoxycorticosterone and cortisol/11-deoxycortisol) fell for both pathways. As expected, cortisone and 11-dehydrocorticosterone levels exceed those of cortisol and corticosterone in umbilical cord blood reflecting the strong placental 11-β-hydroxysteroid-dehydrogenase type 2 (11βHSD2) activity. Dehydroepiandrosterone-sulphate levels are higher in neonates, while both androstenedione and testosterone levels sharply fell. No significant difference in steroid levels could be observed according the gender except higher testosterone concentrations in umbilical cord of boys. Moreover, a strong and negative relationship between testosterone and progesterone levels was recorded in umbilical cord of boys. These adrenal steroidomic profiling demonstrate a deficit in mineralocorticoids (aldosterone, 18-hydroxycorticosterone and corticosterone) and glucocorticoids (cortisol) in term neonates, reflecting either a relative defect in 11-hydroxylase activity or more likely the strong placental 11-β-HSD2 activity. Collectively, these findings should be taken into account for a better understanding of regulatory interactions between placenta and fetal adrenal.
http://ift.tt/2ByGMt8
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
-
▼
Νοεμβρίου
(7424)
-
▼
Νοε 29
(164)
- Editorial board
- Comparative Profiling of Adrenal Steroids in Mater...
- Steroidogenic enzymes, their products and sex ster...
- DIABETES INDUCES MITOCHONDRIAL DYSFUNCTION AND ALT...
- Characterization of equine GST A3-3 as a steroid i...
- Highlights from the 20th Workshop on Vitamin D in ...
- EFFLUX TRANSPORT of ESTROGEN GLUCURONIDES by HUMAN...
- Impact of vitamin D on pregnancy-related disorders...
- Transition from androgenic to neurosteroidal actio...
- Medikamentöse Therapie neuroendokriner Neoplasien ...
- BranchAnalysis2D/3D automates morphometry analyses...
- Enhancement of the mechanical and thermal properti...
- A novel multiscale silver paste for die bonding on...
- Thermal properties of graphene/metal composites wi...
- Primary cutaneous mucoepidermal carcinoma
- Systemic thrombolysis in a patient with massive pu...
- Lyric hearing aid: a rare cause of benign necrotis...
- Follicular bronchiolitis in an HIV-infected indivi...
- Yawning—its anatomy, chemistry, role, and patholog...
- Implementing near real-time vaccine safety surveil...
- Editorial Board/Aims and Scope
- Attitudes about vaccines to prevent Ebola virus di...
- Ethics, pregnancy, and ZIKV vaccine research & dev...
- Randomized Split-face, Controlled Comparison of Tr...
- Randomized Split-face, Controlled Comparison of Tr...
- Anti-tumour necrosis factor-α antibodies and B cel...
- Chemical characterization of PM 2.5 collected from...
- The extent of surgery for benign parotid pathology...
- Acute Chest Syndrome: An Ongoing Challenge for Phy...
- Diet, Lung Function, and Asthma Exacerbations in P...
- Neutrophil–Lymphocyte Ratio in Children with Recur...
- Developing a Mobile Health Intervention for Low-In...
- Acute Chest Syndrome: An Ongoing Challenge for Phy...
- Diet, Lung Function, and Asthma Exacerbations in P...
- Neutrophil–Lymphocyte Ratio in Children with Recur...
- Developing a Mobile Health Intervention for Low-In...
- Epidemiology, biology and therapy of Merkel cell c...
- Quantitative Measurements Versus Receiver Operatin...
- Prognostic Factors for Survival After Transarteria...
- The Study of Clear Cell Renal Cell Carcinoma with ...
- High-risk Plaque and Calcification Detected by Cor...
- Which Preschool Children With Specific Language Im...
- Errata
- Errata
- Errata
- Irinotecan and Oxaliplatin Might Provide Equal Ben...
- Robotic-assisted Transperitoneal Infrarenal Para-a...
- Anastomotic Leakage Using Linear Stapling Device w...
- Association Between PD-L1 Expression and Metabolic...
- A Glissonean Approach with Individual Isolation Du...
- Mucinous Cystic Neoplasms Lined by Abundant Mucino...
- Characterization of Prognostic Factors and the Eff...
- BRAF, NRAS and C-KIT Advanced Melanoma: Clinico-pa...
- Incidence and Risk Factors of Symptomatic Hiatal H...
- A Prospective Study of Intensity-modified Radiatio...
- Pancreatic Mucinous Cystic Neoplasm Communicating ...
- Predictive Factors and a Survival Score for Patien...
- Stereotactic Body Radiation Therapy in Primary and...
- One-pot synthesis of pH-responsive charge-switchab...
- A mitochondrial-targeting near-infrared fluorescen...
- Mechanistic insights into the role of glycosaminog...
- When stem cells meet graphene: Opportunities and c...
- Lingual tonsillectomy in children with Down syndro...
- Making and working of a new electronic resource fo...
- Nodular fasciitis of the temporomandibular joint: ...
- Prognosis of oral cancer: a comparison of the stag...
- Is it better to bend wires occlusally or apically ...
- Retroseptal transconjunctival approach for fractur...
- Tracking the Growth of Tense and Agreement in Chil...
- Evaluation of an Automated Pipeline for Large Scal...
- Option grids in melanoma - an underused tool
- Patient-specific puzzle implant preformed with 3d-...
- The extent of surgery for benign parotid pathology...
- The extent of surgery for benign parotid pathology...
- Comparing Traditional Service Delivery and Telepra...
- Uranium(VI) sorption complexes on silica in the pr...
- Postmortem MRI and histology demonstrate different...
- Intertriginous and Seborrheic Dermatitis-Like Lesi...
- Blistering and Skin Fragility Due to Imatinib Ther...
- Relationship Between Pityriasis Lichenoides and My...
- Intradermal Proliferative Fasciitis Occurring With...
- Young adult e-cigarette use outcome expectancies: ...
- RACK1 is an organ-specific prognostic predictor in...
- Uterus transplantation: A Rapidly Expanding Field
- Complete Atrioventricular Heart Block From an Epil...
- Wide-field en face swept-source optical coherence ...
- A meta-analysis of the association between vocaliz...
- Corticospinal excitability during motor imagery is...
- Acknowledgement to reviewers
- Oral cancer databases: a comprehensive review
- Dermatologist Density and Volume and Costs of Derm...
- Topical Tacalcitol for a Family With Follicular Ke...
- Laboratory Monitoring During Systemic Terbinafine ...
- Allergen Concerns and Popular Skin Care Products
- Allergen Concerns and Popular Skin Care Products
- Allergen Concerns and Popular Skin Care Products—R...
- Preference-Based QOL Measures for Economic Evaluat...
- Vemurafenib for BRAF V600-Mutant Erdheim-Chester D...
- Using first bout effect to study the mechanisms un...
- Indoor allergen levels in settled airborne dust ar...
-
▼
Νοε 29
(164)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Τετάρτη 29 Νοεμβρίου 2017
Comparative Profiling of Adrenal Steroids in Maternal and Umbilical Cord Blood
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
-
▼
Νοεμβρίου
(7424)
-
▼
Νοε 29
(164)
- Editorial board
- Comparative Profiling of Adrenal Steroids in Mater...
- Steroidogenic enzymes, their products and sex ster...
- DIABETES INDUCES MITOCHONDRIAL DYSFUNCTION AND ALT...
- Characterization of equine GST A3-3 as a steroid i...
- Highlights from the 20th Workshop on Vitamin D in ...
- EFFLUX TRANSPORT of ESTROGEN GLUCURONIDES by HUMAN...
- Impact of vitamin D on pregnancy-related disorders...
- Transition from androgenic to neurosteroidal actio...
- Medikamentöse Therapie neuroendokriner Neoplasien ...
- BranchAnalysis2D/3D automates morphometry analyses...
- Enhancement of the mechanical and thermal properti...
- A novel multiscale silver paste for die bonding on...
- Thermal properties of graphene/metal composites wi...
- Primary cutaneous mucoepidermal carcinoma
- Systemic thrombolysis in a patient with massive pu...
- Lyric hearing aid: a rare cause of benign necrotis...
- Follicular bronchiolitis in an HIV-infected indivi...
- Yawning—its anatomy, chemistry, role, and patholog...
- Implementing near real-time vaccine safety surveil...
- Editorial Board/Aims and Scope
- Attitudes about vaccines to prevent Ebola virus di...
- Ethics, pregnancy, and ZIKV vaccine research & dev...
- Randomized Split-face, Controlled Comparison of Tr...
- Randomized Split-face, Controlled Comparison of Tr...
- Anti-tumour necrosis factor-α antibodies and B cel...
- Chemical characterization of PM 2.5 collected from...
- The extent of surgery for benign parotid pathology...
- Acute Chest Syndrome: An Ongoing Challenge for Phy...
- Diet, Lung Function, and Asthma Exacerbations in P...
- Neutrophil–Lymphocyte Ratio in Children with Recur...
- Developing a Mobile Health Intervention for Low-In...
- Acute Chest Syndrome: An Ongoing Challenge for Phy...
- Diet, Lung Function, and Asthma Exacerbations in P...
- Neutrophil–Lymphocyte Ratio in Children with Recur...
- Developing a Mobile Health Intervention for Low-In...
- Epidemiology, biology and therapy of Merkel cell c...
- Quantitative Measurements Versus Receiver Operatin...
- Prognostic Factors for Survival After Transarteria...
- The Study of Clear Cell Renal Cell Carcinoma with ...
- High-risk Plaque and Calcification Detected by Cor...
- Which Preschool Children With Specific Language Im...
- Errata
- Errata
- Errata
- Irinotecan and Oxaliplatin Might Provide Equal Ben...
- Robotic-assisted Transperitoneal Infrarenal Para-a...
- Anastomotic Leakage Using Linear Stapling Device w...
- Association Between PD-L1 Expression and Metabolic...
- A Glissonean Approach with Individual Isolation Du...
- Mucinous Cystic Neoplasms Lined by Abundant Mucino...
- Characterization of Prognostic Factors and the Eff...
- BRAF, NRAS and C-KIT Advanced Melanoma: Clinico-pa...
- Incidence and Risk Factors of Symptomatic Hiatal H...
- A Prospective Study of Intensity-modified Radiatio...
- Pancreatic Mucinous Cystic Neoplasm Communicating ...
- Predictive Factors and a Survival Score for Patien...
- Stereotactic Body Radiation Therapy in Primary and...
- One-pot synthesis of pH-responsive charge-switchab...
- A mitochondrial-targeting near-infrared fluorescen...
- Mechanistic insights into the role of glycosaminog...
- When stem cells meet graphene: Opportunities and c...
- Lingual tonsillectomy in children with Down syndro...
- Making and working of a new electronic resource fo...
- Nodular fasciitis of the temporomandibular joint: ...
- Prognosis of oral cancer: a comparison of the stag...
- Is it better to bend wires occlusally or apically ...
- Retroseptal transconjunctival approach for fractur...
- Tracking the Growth of Tense and Agreement in Chil...
- Evaluation of an Automated Pipeline for Large Scal...
- Option grids in melanoma - an underused tool
- Patient-specific puzzle implant preformed with 3d-...
- The extent of surgery for benign parotid pathology...
- The extent of surgery for benign parotid pathology...
- Comparing Traditional Service Delivery and Telepra...
- Uranium(VI) sorption complexes on silica in the pr...
- Postmortem MRI and histology demonstrate different...
- Intertriginous and Seborrheic Dermatitis-Like Lesi...
- Blistering and Skin Fragility Due to Imatinib Ther...
- Relationship Between Pityriasis Lichenoides and My...
- Intradermal Proliferative Fasciitis Occurring With...
- Young adult e-cigarette use outcome expectancies: ...
- RACK1 is an organ-specific prognostic predictor in...
- Uterus transplantation: A Rapidly Expanding Field
- Complete Atrioventricular Heart Block From an Epil...
- Wide-field en face swept-source optical coherence ...
- A meta-analysis of the association between vocaliz...
- Corticospinal excitability during motor imagery is...
- Acknowledgement to reviewers
- Oral cancer databases: a comprehensive review
- Dermatologist Density and Volume and Costs of Derm...
- Topical Tacalcitol for a Family With Follicular Ke...
- Laboratory Monitoring During Systemic Terbinafine ...
- Allergen Concerns and Popular Skin Care Products
- Allergen Concerns and Popular Skin Care Products
- Allergen Concerns and Popular Skin Care Products—R...
- Preference-Based QOL Measures for Economic Evaluat...
- Vemurafenib for BRAF V600-Mutant Erdheim-Chester D...
- Using first bout effect to study the mechanisms un...
- Indoor allergen levels in settled airborne dust ar...
-
▼
Νοε 29
(164)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου