Hormone-dependent medial preoptic/lumbar spinal cord/autonomic coordination supporting male sexual behaviors

Publication date: Available online 31 October 2017
Source:Molecular and Cellular Endocrinology
Author(s): Donald W. Pfaff, Michael J. Baum
Testosterone (T) can act directly through neural androgen receptors (AR) to facilitate male sexual behavior; however, T's metabolites also can play complicated and interesting roles in the control of mating. One metabolite, dihydrotestosterone (DHT) binds to AR with significantly greater affinity than that of T. Is that important behaviorally? Another metabolite, estradiol (E), offers a potential alternative route of facilitating male mating behavior by acting through estradiol receptors (ER). In this review we explore the roles and relative importance of T as well as E and DHT at various levels of the neuroaxis for the activation of male sex behavior in common laboratory animals and, when relevant research findings are available, in man.



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