Increased stool immunoglobulin A level in children with autism spectrum disorders

Publication date: Available online 6 November 2017
Source:Research in Developmental Disabilities
Author(s): Jiaxiu Zhou, Fusheng He, Feng Yang, Zheng Yang, Yingjun Xie, Shaoming Zhou, Jingwen Liang, Ruihuan Xu, Yan Wang, Hailiang Guo, Wenhao Zhou, Mingbang Wang
BackgroundThere are currently no effective treatments for the core symptoms of autism spectrum disorders (ASDs). However, alleviating gastrointestinal (GI) problems, which are prevalent in ASD patients, can significantly improve the core symptoms of autism. Previous studies have associated GI disorders in ASD patients with abnormal gut microbiota, although few disease-related microorganisms have been identified. Considering that the gut microbiome affects the intestinal immune system and the patient's behavior, and that immunoglobulin A (IgA) is the main antibody secreted by intestinal immune cells, we investigated stool IgA content as a means of understanding the gut immune status of ASD patients. The IgA level in gut can be used as factor to know the Gene x Environment interactions and diagnose of ASDs.MethodsWe enrolled 43 ASD patients and 31 gender- and age-matched healthy children. Stool IgA content was measured by enzyme-linked immunosorbent assay.ResultsWe found that IgA levels were significantly higher in stool samples from ASD patients than from healthy children (p<0.05, Student's t test).ConclusionsThis finding may suggest the presence of gut immune abnormalities in ASD patients. Further studies with larger patient and control cohorts will be necessary to determine whether stool IgA levels can be used as a biomarker for ASDs.



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