A novel ion-activated in situ gelling ophthalmic delivery system based on kappa-carrageenan for acyclovir.

A novel ion-activated in situ gelling ophthalmic delivery system based on kappa-carrageenan for acyclovir.

Drug Dev Ind Pharm. 2017 Dec 06;:1-25

Authors: Li P, Wang S, Chen H, Zhang S, Yu S, Li Y, Cui M, Pan W, Yang X

Abstract
The aim of this study was to prepare and evaluate ion-activated in-situ gel ophthalmic drug delivery system based on kappa-carrageenan (KC), using acyclovir as a model drug, hydroxypropyl methylcellulose (HPMC) as the viscosity agent and hydroxypropyl-β-cyclodextrin (HP-β-CD) as the penetration enhancer. The two ternary phase diagrams exhibited the effect of K+ and Ca2+ on the sol-to-gel transition, which turned out that KC was more sensitive to K+. The optimal ophthalmic matrix (prepared from KC and HPMC) was optimized with in-vitro drug release test. The apparent permeability coefficient of acyclovir under 2% HP-β-CD was found to have dramatically increased (2.16-ploid) than that of conventional eye drops (P < 0.05). The ion-activated in-situ gel based on KC significantly delayed drug release and its bioavailability could be improved in comparison with the conventional eye drops. Hence, it has the potential to be a novel kind of ocular drug delivery system.

PMID: 29212376 [PubMed - as supplied by publisher]

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